Prepare your defense against the oncoming waves of creeps. Don't let them complete the path. Do that by building your base that consists of defense towers along the way.
Instead of building towers and defending against hordes of monsters, play the opposite as an evil mage that builds his army from the ground up to dominate the lands.
Help the space rebellions to drive the evil spacelord out of the Minoria system. Deploy, defend and attack their solar systems to take control of the galaxy.